Toxic shame and self-sabotage are very common experiences that need a multi-layered approach to address their physical manifestations like toxic biofilms, and also the mental, emotional and spiritual aspects. Naturopathic medicine, including clearing pathogens, and nourishing tissues are key. Pleasure practices are an essential aspect for people healing toxic biofilms, toxic shame and self-sabotage, especially for those with a history of sexual trauma. In addition, special care and techniques are needed to re-orient to our highest good and reclaim wholeness.